Research peptides · Third-party tested
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Synthetic tetrapeptide, sold for laboratory research.
Identity
Epithalon is a lab-made version of a four-amino-acid chain, Ala-Glu-Asp-Gly, that researchers first identified inside an extract of the pineal gland, a small structure deep in the brain tied to the body's daily clock. A St. Petersburg research group synthesized the short peptide themselves after finding this pattern in the gland extract. It belongs to a small family of short bioregulator peptides that this same group has studied for several decades.
Epithalon is a synthetic tetrapeptide of 4 amino acid residues. SBz Industries sells it for laboratory research.
Research
In plain terms, with a link to every study. The most useful thing to notice is what each study was done in.
The bulk of epithalon's research base comes from a handful of St. Petersburg labs, pulled together in a 2025 review covering roughly 25 years of work. Studies range from testing the peptide directly on human cells growing in a lab dish to small studies involving rats and, in one case, human patients. Independent replication outside that original research group is limited, which the 2025 review itself flags as a gap.
review2025
A 2025 review gathered roughly 25 years of lab dish, animal, and computer modeling studies on epithalon, describing reported effects on melatonin production, immune signaling molecules, and enzyme activity, while noting that some of its mechanisms are still not fully worked out.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj and colleagues, International Journal of Molecular Sciences
cells2003
Researchers added epithalon to human fetal skin cells growing in a lab dish that had lost the ability to make telomerase, an enzyme linked to how many times a cell can divide, and reported that the peptide turned telomerase activity back on and lengthened the cells' telomeres.
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Khavinson and colleagues, Bulletin of Experimental Biology and Medicine
rats and people2002
The same research group gave epithalon to rats bred with an inherited retina condition and separately to a small group of patients with degenerative retina changes, reporting stronger electrical activity in the rat retinas and a positive clinical response in 90 percent of the human cases.
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Khavinson and colleagues, Neuro Endocrinology Letters
Each study links to its record on PubMed, the US National Library of Medicine database. Checked 25 September 2026.
Handling
Lyophilized: -20C, protected from light. Reconstituted: 2-8C.
Give the vial twenty minutes on the bench before opening it, so water does not condense onto the powder.
Slowly, down the inside wall of the vial, never straight onto the powder.
Leave it alone until it clears. Do not shake it. Shaking damages the peptide.
Once mixed, it breaks down much faster than the dry powder. Keep it cold and dark.
Documentation
An independent lab tests every compound we sell. It confirms the compound is what the label says and measures purity by HPLC.
The latest certificate is on the product page, so you can read the result before you order.
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Questions
Epithalon is a lab-made version of a four-amino-acid chain, Ala-Glu-Asp-Gly, that researchers first identified inside an extract of the pineal gland, a small structure deep in the brain tied to the body's daily clock. A St. Petersburg research group synthesized the short peptide themselves after finding this pattern in the gland extract. It belongs to a small family of short bioregulator peptides that this same group has studied for several decades. SBz Industries sells it for laboratory research only.
Yes, but only in small, older studies from one research group, including one on retina changes in a handful of patients. There is no large modern human trial.
One lab dish study on human skin cells reported that it turned on telomerase and lengthened telomeres in that cell culture. That finding has not been independently repeated by other labs at scale.
Epithalon ships as a freeze-dried powder. Mix it with bacteriostatic water, added slowly down the inside wall of the vial, and let it dissolve without shaking. The researcher decides the working concentration, not us, and we publish no protocols.
Lyophilized: -20C, protected from light. Reconstituted: 2-8C. Vials ship in plain outer packaging with no product name on the outside.
Yes. An independent lab tests every compound: it confirms the compound is what the label says and measures purity by HPLC. The latest certificate is on the product page, and you can read it before you order.
Researchers and institutions, 21 or over. By ordering you confirm the material is for laboratory research and will not be used in humans or animals.
Order
Every compound is third-party tested, with the certificate on its product page. Every order ships in plain packaging.