Research peptides · Third-party tested
You're in
It is saved in this browser and applies at checkout by itself. We also emailed it to you.
Access closed
Nothing on this site is available to anyone under 21, and nothing on it is intended for personal use at any age.
Online ordering is open. Ships in 1 to 2 business days. Tracked 2-day shipping, plain box. Every compound third-party tested
Type to search. Enter opens the first match. Esc closes.
Both are aimed at the pituitary cells that make growth hormone. They get there through different receptors, they were made decades apart, and one is five amino acids long while the other is twenty-nine.
The short answer
The brain tells the pituitary gland to release growth hormone with a signal called GHRH. Sermorelin is a lab-made copy of the first 29 amino acids of that signal, the shortest piece that still does the full job of the original [1]. It works on the GHRH receptor [2].
Ipamorelin takes a different route. It is a tiny peptide, five amino acids, that works on the receptor for ghrelin, a hormone from the stomach [5] [7]. Different door, same room.
If sermorelin sounds familiar, it is a close relative of CJC-1295, which is built on the same 29-amino-acid piece with a few changes.
Side by side
| Ipamorelin | Sermorelin | |
|---|---|---|
| What it is | A small lab-designed peptide | A copy of the first 29 amino acids of GHRH |
| Length | 5 amino acids | 29 amino acids |
| Receptor | Ghrelin (growth hormone secretagogue) receptor | GHRH receptor |
| First described | 1998, Novo Nordisk | Studied from the 1980s |
| Relatives | Older lab-made releasing peptides such as GHRP-6 | CJC-1295, tesamorelin |
| Sold here | In the CJC-1295 + Ipamorelin blend, $55 | On its own, $55 |
| Storage | Powder in the freezer at minus 20 C, away from light. Once mixed, in the fridge at 2 to 8 C. | |
The research
With a link to every paper. Most of this is cells in a dish and rats.
Does the short piece work like the full signal? A 1991 study in rat pituitary cells compared the full natural signal with its 29-amino-acid piece, the rat version of what sermorelin copies [3].
How long does it last? A 1992 study put the 29-amino-acid piece into rat blood serum and liver in a test tube and timed how fast it broke down. In serum, half of it was gone in about 18 minutes [4]. That short life is the problem CJC-1295 was later built to solve.
The discovery. Novo Nordisk chemists described it in 1998 and tested it in rat pituitary cells, in rats and in pigs. In the pig tests it did not raise the stress hormones ACTH and cortisol the way two older compounds of the same type did, which is why the paper calls it selective [5].
A longer rat study. In 1999 the same company gave it to adult female rats for 15 days and measured how fast the shin bone lengthened [6].
Questions
Which receptor each one uses. Sermorelin is a copy of the first 29 amino acids of GHRH and works on the GHRH receptor. Ipamorelin is a five-amino-acid peptide that works on the ghrelin receptor. Both receptors are on the pituitary cells that make growth hormone.
Close relatives, not the same. Both are built on the first 29 amino acids of GHRH. CJC-1295 has four changed amino acids, and the original version also carries a chemical hook that makes it last far longer. Sermorelin is the plain 29-amino-acid piece.
Sermorelin. The 29-amino-acid piece of GHRH was being studied in the 1980s. Ipamorelin was first described by Novo Nordisk in 1998.
Not at the moment. It is sold here inside the CJC-1295 + Ipamorelin blend, $55 a vial. Sermorelin is sold on its own, $55 a vial.
Yes. It was once approved in the United States, and the manufacturer later discontinued it. What is sold here is research material for laboratory use, not that product.
Both are sold for laboratory research and nothing else. They are not drugs or supplements, and they are not for human or veterinary use.
Sources
Each one links to its record on PubMed, the US National Library of Medicine database. Checked on 29 September 2026.
In the catalog
For laboratory research use only. Every vial ships in a plain box with a packing slip.
Elsewhere
