Research peptides · Third-party tested
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Synthetic tripeptide, sold for laboratory research.
Identity
KPV is a tiny three-amino-acid chain, lysine, proline, and valine, that's actually the tail end of a much longer natural hormone, alpha-MSH. Researchers found that this small fragment alone can reproduce some of the parent hormone's calming effect on immune signaling, without needing the rest of the molecule. It has mostly been studied as a research tool for understanding how immune signaling works at the cell level, first in gut tissue and later in skin cells.
KPV is a synthetic tripeptide of 3 amino acid residues. SBz Industries sells it for laboratory research.
Research
In plain terms, with a link to every study. The most useful thing to notice is what each study was done in.
KPV's best-known study is a 2008 paper out of Emory University that tested it in mice with chemically irritated colons, tracing how the peptide gets into cells and what it does once inside. A separate paper looked at how KPV signals inside human skin cells growing in a dish. Both studies are more about mechanism than about outcomes in whole, healthy people.
mice2008
Mice with two different types of chemically induced colon irritation were given KPV in their drinking water; researchers tracked how the peptide entered cells through a specific transporter protein and measured tissue damage and immune signaling molecule levels, finding both were lower in the treated mice.
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Dalmasso and colleagues, Gastroenterology
cells2004
Human skin cells grown in a lab dish were exposed to KPV and related peptides, and researchers measured calcium signaling inside the cells, finding KPV triggered a rapid calcium response only when a second compound blocking a separate signaling pathway was also present.
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.
Elliott and colleagues, Journal of Investigative Dermatology
Each study links to its record on PubMed, the US National Library of Medicine database. Checked 25 September 2026.
Handling
Lyophilized: -20C, protected from light. Reconstituted: 2-8C.
Give the vial twenty minutes on the bench before opening it, so water does not condense onto the powder.
Slowly, down the inside wall of the vial, never straight onto the powder.
Leave it alone until it clears. Do not shake it. Shaking damages the peptide.
Once mixed, it breaks down much faster than the dry powder. Keep it cold and dark.
Documentation
An independent lab tests every compound we sell. It confirms the compound is what the label says and measures purity by HPLC.
The latest certificate is on the product page, so you can read the result before you order.
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Questions
KPV is a tiny three-amino-acid chain, lysine, proline, and valine, that's actually the tail end of a much longer natural hormone, alpha-MSH. Researchers found that this small fragment alone can reproduce some of the parent hormone's calming effect on immune signaling, without needing the rest of the molecule. It has mostly been studied as a research tool for understanding how immune signaling works at the cell level, first in gut tissue and later in skin cells. SBz Industries sells it for laboratory research only.
Not in a published human trial found here. The research is in mice and in human cells grown outside the body in a lab dish.
It is the last three amino acids of alpha-MSH, a longer natural hormone, and researchers found this short piece alone can reproduce part of what the full hormone does.
KPV ships as a freeze-dried powder. Mix it with bacteriostatic water, added slowly down the inside wall of the vial, and let it dissolve without shaking. The researcher decides the working concentration, not us, and we publish no protocols.
Lyophilized: -20C, protected from light. Reconstituted: 2-8C. Vials ship in plain outer packaging with no product name on the outside.
Yes. An independent lab tests every compound: it confirms the compound is what the label says and measures purity by HPLC. The latest certificate is on the product page, and you can read it before you order.
Researchers and institutions, 21 or over. By ordering you confirm the material is for laboratory research and will not be used in humans or animals.
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Every compound is third-party tested, with the certificate on its product page. Every order ships in plain packaging.