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Mitochondrial-derived peptide, sold for laboratory research.
Identity
MOTS-c is a short, 16-amino-acid peptide that mitochondria, the energy-producing structures inside cells, build from a stretch of DNA once dismissed as junk rather than a working gene. A University of Southern California team led by Changhan Lee first described it in 2015. Unlike most hormones, which come from glands, MOTS-c is made inside the cell's own power plants and appears to signal back out from there.
MOTS-c is a mitochondrial-derived peptide of 16 amino acid residues. SBz Industries sells it for laboratory research.
Research
In plain terms, with a link to every study. The most useful thing to notice is what each study was done in.
MOTS-c research is still young and dominated by mouse and cell studies from the lab that discovered it, plus a growing number of follow-up papers on its role in metabolism and aging. Human data exists but is almost entirely observational, measuring the peptide's natural levels in blood rather than testing it as an injected treatment. No published human trial has given people MOTS-c and tracked what happens next.
mice2015
Gave the peptide to older mice and to mice fed a high-fat diet, then tracked body weight and blood sugar handling over time. Treated mice gained less weight and handled blood sugar better than untreated mice on the same diet.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee and colleagues, Cell Metabolism
review2023
Summarized the cell and animal research on MOTS-c published through 2023, covering how it is made, where it travels in the body, and what conditions researchers have tested it against in the lab. The authors are upfront that almost all of this work is preclinical, with no established way to use it in people.
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng and colleagues, Frontiers in Endocrinology
people2019
Measured the body's own MOTS-c in the blood of two groups of women, ahead of a fat infusion, just after it, and again after eight weeks of exercise training. Nobody was given MOTS-c; the study only tracked the natural levels.
Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.
Ramanjaneya and colleagues, Clinical Endocrinology
Each study links to its record on PubMed, the US National Library of Medicine database. Checked 25 September 2026.
Handling
Lyophilized: -20C, protected from light. Reconstituted: 2-8C.
Give the vial twenty minutes on the bench before opening it, so water does not condense onto the powder.
Slowly, down the inside wall of the vial, never straight onto the powder.
Leave it alone until it clears. Do not shake it. Shaking damages the peptide.
Once mixed, it breaks down much faster than the dry powder. Keep it cold and dark.
Documentation
An independent lab tests every compound we sell. It confirms the compound is what the label says and measures purity by HPLC.
The latest certificate is on the product page, so you can read the result before you order.
See the certificateRead next
Questions
MOTS-c is a short, 16-amino-acid peptide that mitochondria, the energy-producing structures inside cells, build from a stretch of DNA once dismissed as junk rather than a working gene. A University of Southern California team led by Changhan Lee first described it in 2015. Unlike most hormones, which come from glands, MOTS-c is made inside the cell's own power plants and appears to signal back out from there. SBz Industries sells it for laboratory research only.
Only by measuring the peptide's natural levels in blood. No published trial has given people MOTS-c and monitored them afterward, that treatment research is all in mice.
In mice that were older or fed a high-fat diet, researchers linked the peptide to better blood sugar handling and less weight gain compared with untreated mice on the same diet.
MOTS-c ships as a freeze-dried powder. Mix it with bacteriostatic water, added slowly down the inside wall of the vial, and let it dissolve without shaking. The researcher decides the working concentration, not us, and we publish no protocols.
Lyophilized: -20C, protected from light. Reconstituted: 2-8C. Vials ship in plain outer packaging with no product name on the outside.
Yes. An independent lab tests every compound: it confirms the compound is what the label says and measures purity by HPLC. The latest certificate is on the product page, and you can read it before you order.
Researchers and institutions, 21 or over. By ordering you confirm the material is for laboratory research and will not be used in humans or animals.
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Every compound is third-party tested, with the certificate on its product page. Every order ships in plain packaging.