SS-31

Synthetic mitochondria-targeting tetrapeptide, sold for laboratory research.

4: residues
2: sizes
HPLC: purity, third-party tested

from $40per vial

Identity

What SS-31 is

SS-31, known by its drug name elamipretide, is a small lab-made peptide built to reach the inner membrane of mitochondria, the compartments inside cells that produce energy. It binds to a fat molecule called cardiolipin that sits on that inner membrane. It has gone through more human testing than most research peptides, including a placebo-controlled trial in people with a rare inherited condition that disrupts energy production in the heart and muscles, though it remains an investigational drug without full approval.

SS-31 is a synthetic mitochondria-targeting tetrapeptide of 4 amino acid residues. SBz Industries sells it for laboratory research.

CAS number: 736992-21-5
Residue count: 4
Compound class: Synthetic mitochondria-targeting tetrapeptide
Appearance: White lyophilized powder
Solubility: Soluble in bacteriostatic water
Storage: Lyophilized: -20C, protected from light. Reconstituted: 2-8C.
Available sizes: 10 mg, 50 mg

Research

What the research has looked at

In plain terms, with a link to every study. The most useful thing to notice is what each study was done in.

Elamipretide has been studied in cell and animal models tied to heart, muscle, and eye function, and in several human trials run by its manufacturer. A 2025 review pulled together this lab and clinical evidence across multiple named trials, including work in a rare inherited condition, a muscle-weakness condition, and a heart-pump condition.

people2021

Twelve people with a rare inherited condition that disrupts energy production in heart and muscle cells were randomized to receive elamipretide or a placebo for 12 weeks each in a crossover design, then 10 of them continued on elamipretide alone for up to 36 weeks. Researchers measured how far participants could walk in 6 minutes and tracked a symptom scale; the head-to-head comparison during the blinded phase did not reach statistical significance, though the longer open period that followed showed improvement on both measures.

A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism.
Thompson and colleagues, Genetics in Medicine

review2025

This review summarizes lab and animal work on how elamipretide binds cardiolipin and holds together mitochondrial structure, and lists several named human trials, including studies in a rare inherited heart-and-muscle condition, a muscle-weakness condition, and a heart-pump condition.

Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.
Tung and colleagues, International Journal of Molecular Sciences

Each study links to its record on PubMed, the US National Library of Medicine database. Checked 25 September 2026.

Handling

Mixing and storage

Lyophilized: -20C, protected from light. Reconstituted: 2-8C.

Full handling guide

01
Let it warm up
Give the vial twenty minutes on the bench before opening it, so water does not condense onto the powder.
02
Add bacteriostatic water
Slowly, down the inside wall of the vial, never straight onto the powder.
03
Let it dissolve
Leave it alone until it clears. Do not shake it. Shaking damages the peptide.
04
Refrigerate and use
Once mixed, it breaks down much faster than the dry powder. Keep it cold and dark.

Documentation

Tested before it goes on sale

An independent lab tests every compound we sell. It confirms the compound is what the label says and measures purity by HPLC.

The latest certificate is on the product page, so you can read the result before you order.

See the certificate

More on SS-31

SS-31 product pageSizes, documentation and the latest certificate.SS-31 in the compound referenceStructure, origin and molecular target.SLU-PP-332 vs SS-31Side by side.5-Amino-1MQ vs SS-31Side by side.How to read a certificate of analysisThe fields worth checking before an order.Reconstitution and handlingDiluent down the glass, never onto the cake.Bacteriostatic waterShelf life, volumes and what the preservative does.Storage, stability and degradationWhat each condition buys, in weeks and months.

Questions

Common questions about SS-31

What is SS-31?

SS-31, known by its drug name elamipretide, is a small lab-made peptide built to reach the inner membrane of mitochondria, the compartments inside cells that produce energy. It binds to a fat molecule called cardiolipin that sits on that inner membrane. It has gone through more human testing than most research peptides, including a placebo-controlled trial in people with a rare inherited condition that disrupts energy production in the heart and muscles, though it remains an investigational drug without full approval. SBz Industries sells it for laboratory research only.

Is SS-31 the same thing as elamipretide?

Yes. SS-31 is the laboratory research name, and elamipretide is the same molecule's drug name used in clinical trials.

Is elamipretide FDA approved?

As of the published research reviewed here, elamipretide remains an investigational drug tested in clinical trials rather than a fully approved medicine.

How is SS-31 reconstituted?

SS-31 ships as a freeze-dried powder. Mix it with bacteriostatic water, added slowly down the inside wall of the vial, and let it dissolve without shaking. The researcher decides the working concentration, not us, and we publish no protocols.

How should SS-31 be stored?

Lyophilized: -20C, protected from light. Reconstituted: 2-8C. Vials ship in plain outer packaging with no product name on the outside.

Is SS-31 tested, and can I see the results?

Yes. An independent lab tests every compound: it confirms the compound is what the label says and measures purity by HPLC. The latest certificate is on the product page, and you can read it before you order.

Who is permitted to purchase SS-31?

Researchers and institutions, 21 or over. By ordering you confirm the material is for laboratory research and will not be used in humans or animals.

Also in cellular and cofactors

Research library

NAD+Pyridine dinucleotide coenzyme GlutathioneEndogenous tripeptide thiol L-CarnitineQuaternary ammonium compound 5-Amino-1MQQuinolinium small molecule SLU-PP-332 MOTS-cMitochondrial-derived peptide

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SS-31, third-party tested

Every compound is third-party tested, with the certificate on its product page. Every order ships in plain packaging.

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SS-31

What SS-31 is

What the research has looked at

Mixing and storage

Let it warm up

Add bacteriostatic water

Let it dissolve

Refrigerate and use