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Synthetic thymosin beta-4 fragment, sold for laboratory research.
Identity
TB-500 is a lab-made piece of a longer natural protein called thymosin beta-4. Picture the full protein as an entire book and TB-500 as one page copied out of it, the section researchers believe drives the protein's effect on cell movement. Most of the famous early research used the whole book, not the single page sold as TB-500 today.
TB-500 is a synthetic thymosin beta-4 fragment. SBz Industries sells it for laboratory research.
Research
In plain terms, with a link to every study. The most useful thing to notice is what each study was done in.
Research specifically on the TB-500 fragment is limited and mostly recent, coming out of rat models of tendon repair. The much larger and older body of research on thymosin beta-4, the full protein, includes rat wound work from the late 1990s, but that research does not automatically carry over to the shorter TB-500 fragment sold now.
rats1999
This classic 1999 study tested the full thymosin beta-4 protein, not the TB-500 fragment, on skin wounds cut into rats and measured how much new skin covered the wound over 7 days. Wounds treated with the full protein closed over faster and showed more new blood vessel growth and collagen than untreated wounds.
Thymosin beta4 accelerates wound healing.
Malinda and colleagues, Journal of Investigative Dermatology
rats2026
Thirty-two rats had their Achilles tendon cut and surgically repaired, then were split into four groups of eight: untreated, BPC-157, TB-500, or both together. Researchers measured how much force the repaired tendon could take before tearing and examined the tissue under a microscope; the TB-500 group needed more force to tear the tendon than untreated controls.
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
Biçer and colleagues, Joint Diseases and Related Surgery
Each study links to its record on PubMed, the US National Library of Medicine database. Checked 25 September 2026.
Handling
Lyophilized: -20C, protected from light. Reconstituted: 2-8C.
Give the vial twenty minutes on the bench before opening it, so water does not condense onto the powder.
Slowly, down the inside wall of the vial, never straight onto the powder.
Leave it alone until it clears. Do not shake it. Shaking damages the peptide.
Once mixed, it breaks down much faster than the dry powder. Keep it cold and dark.
Documentation
An independent lab tests every compound we sell. It confirms the compound is what the label says and measures purity by HPLC.
The latest certificate is on the product page, so you can read the result before you order.
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Questions
TB-500 is a lab-made piece of a longer natural protein called thymosin beta-4. Picture the full protein as an entire book and TB-500 as one page copied out of it, the section researchers believe drives the protein's effect on cell movement. Most of the famous early research used the whole book, not the single page sold as TB-500 today. SBz Industries sells it for laboratory research only.
No. TB-500 is a synthetic fragment copied from a section of the full thymosin beta-4 protein. They are related but not identical, and older research citing thymosin beta-4 usually used the complete protein.
No published human trial on TB-500 was found. Current published research is limited to rat models.
TB-500 ships as a freeze-dried powder. Mix it with bacteriostatic water, added slowly down the inside wall of the vial, and let it dissolve without shaking. The researcher decides the working concentration, not us, and we publish no protocols.
Lyophilized: -20C, protected from light. Reconstituted: 2-8C. Vials ship in plain outer packaging with no product name on the outside.
Yes. An independent lab tests every compound: it confirms the compound is what the label says and measures purity by HPLC. The latest certificate is on the product page, and you can read it before you order.
Researchers and institutions, 21 or over. By ordering you confirm the material is for laboratory research and will not be used in humans or animals.
Order
Every compound is third-party tested, with the certificate on its product page. Every order ships in plain packaging.